Native River has been ruled out of the Cheltenham Gold Cup with a suspensory injury.
Star Irish jumper Sizing John has been ruled out for the rest of the season after suffering another injury setback.
Sizing John will not defend his crown in the Cheltenham Gold Cup next week, trainer Jessica Harrington has announced.
Trainer Noel Meade now has his sights firmly on the Cheltenham Gold Cup with Road To Respect after his victory in the Leopardstown Christmas Chase.
Might Bite has advanced his Cheltenham Gold Cup claims with victory in the King George VI Chase at Kempton.